This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state ...

With intensifying global warming and climate change, drought has become a major threat to global agriculture, impacting crop ...

While their functions are diverse, myosins are similar in structure. NMII is so much like cardiac myosin, which keeps the ...

Myosin Therapeutics, a clinical-stage biotechnology company advancing first-in-class therapies targeting molecular motor proteins, announced the publication of two major papers in the journal Cell ...

However, boron is often scarce in soil, particularly in arid regions, making passive absorption impossible. To combat this, plants have evolved proteins that actively transport boron from the soil ...

Myosin XI is a plant-specific motor protein that moves along actin filaments and helps in intracellular organelle transport.

Myosin VI is a unique reverse-directed motor protein in the myosin family. The D179Y mutation in Myosin VI is associated with deafness in mammals. This mutation destroys the processive motion of ...

JUPITER, Fla., Feb. 26, 2025 /PRNewswire/ -- Myosin Therapeutics, Inc., a biotechnology company developing novel therapies for cancer and neurological disorders, has closed its second seed funding ...

The study reveals 44 differentially expressed proteins in cleft palate models, shedding light on molecular mechanisms and ...

The novel cardiac myosin inhibitor aficamten improved peak oxygen uptake in symptomatic obstructive hypertrophic cardiomyopathy (HCM), the pivotal SEQUOIA-HCM trial showed. At 24 weeks, the mean ...

Myosin modulators were identified by testing these selected compounds using biochemical assay. The biochemical assays were made using bovine cardiac myosin S1 and rabbit skeletal F-actin.

Actin isoforms organize into distinct networks that are essential for the normal function of eukaryotic cells. Despite a high level of sequence and structure conservation, subtle differences in their ...