Maintaining mitochondrial DNA (mtDNA) integrity is crucial for cardiomyocyte function, and its disruption plays a significant role in ischemia/reperfusion (I/R) injury.

Mitochondrial bioenergetics is vital to cellular functions and survival, and dysregulated oxidative-phosphorylation (OXPHOS) may promote neonatal HI brain injury (Niatsetskaya et al., 2012).

Abstract Background— Whether alterations in mitochondrial morphology affect the susceptibility of the heart to ischemia/reperfusion injury is unknown. We hypothesized that modulating mitochondrial ...

Mitochondrial oxidative phosphorylation is the major pathway for ATP production in eukaryotic cells (Figure 1). During this process, cellular redox energy from the breakdown of food is converted ...

Microcirculation disturbance and organ injury after intestinal I/R are complicated pathological processes that mainly involve metabolic injury and oxidative stress during ischemia and reperfusion.

Cardiac ischemia-reperfusion (I/R) injury is associated with mitochondrial dysfunction. Recent studies have reported that mitochondrial function is determined by mitochondrial dynamics. Here, we ...

Numerous therapies have been tested in preclinical models to try to reduce ischemia/reperfusion injury. 4 In the setting of clinical ST-elevation–myocardial infarction (STEMI), various adjunctive ...

A critical factor mediating reperfusion injury of the heart is the mitochondrial permeability transition pore (MPTP), the opening of which causes mitochondrial swelling with release of proapoptotic ...