Universitat de Barcelona researchers have developed a new method for characterizing solute-solvent interactions in electrokinetic systems.

University of Utah researchers have developed a material that addresses an urgent environmental challenge: the real-time ...

The end of the non-dom tax regime is already causing a UK wealth exodus but chancellor Rachel Reeves may row back on inheritance tax changes for non-doms.

Non-covalent interactions, such as hydrogen bonding, electrostatic forces, and dispersion forces, (Schneider, 2022), largely determine the interaction energy between gas molecules and the MOF. The ...

We find that covalent attachment of EPI-002 and EPI-7170 increases the population of collapsed helical transactivation domain conformations relative to the populations observed in non-covalent binding ...

Phase 2 study of DZD8586, a non-covalent BBB penetrant LYN/BTK dual inhibitor, as monotherapy in relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL; TAI-SHAN9).

Phase 1/2 studies of DZD8586 in CLL/SLL patients after covalent or non-covalent BTK inhibitors and BTK degraders. A phase 1/2 study to evaluate the safety and efficacy of XNW5004, a selective EZH2 ...

Amoxicillin has interactions with some other drugs. Examples include warfarin, methotrexate, and allopurinol. Talk with your doctor to avoid potentially harmful effects from amoxicillin interactions.

Chemoproteomics has become a major approach to discover new protein-ligand interactions for biomedical research and drug discovery. The success of multiple covalent drugs against proteins once deemed ...

Sustained reactivation of mutant p53 drives durable anti-tumor activity across models, including KRAS co-mutant tumors FMC-220 selectively stabilizes p53 Y220C at lower doses, overcoming key ...

The Frontier™ Platform also enabled the discovery of FMC-220, the first covalent p53Y220C activator, designed to overcome the limitations of potency and durability seen in non-covalent approaches.