The key to this is the modification of the original ligand with a reactive "handle" that allows it to react with a nucleobase at the RNA binding site. This was first demonstrated in vitro and in ...

Highly specific interactions between biomolecules, interactions such as cell-surface ligand-receptor recognition, antibody-antigen binding, and complementary double-stranded DNA hybridization, play a ...

dynamics and ligand binding via unnatural amino acid incorporation. At Wilkes University, Henkels will be teaching general chemistry and biochemistry lecture and laboratory courses, as well as ...