and that the structure is very likely to determine the function,” says Li. But computational tools for predicting RNA structure lag behind their protein equivalents. Even AlphaFold3, the latest ...

These challenges need to be addressed alongside scientific research for RNA-based therapeutics to achieve their full potential. The LNP encapsulation process is intricate and demands precise ...

Basic Research Guides the Development of New Therapeutic Strategies Knowledge of the structure and function of catalytic RNA is important for improving existing ribozymes and developing new ones.

In Biology 101, we learn that RNA is a single ... To study—and potentially modify—the functions of non-coding RNAs, we need to determine their structure. Scientists from Lawrence Berkeley ...

The crystal structure of the ... Indeed SRP RNA may be required for GTPase activity because it positions the arginine to perform its catalytic function. Finally, it is not at all clear why a ...

In this article, we define RNA polymerase and further explore its various functions throughout cell biology. RNA polymerase is a multi-unit enzyme that synthesizes RNA molecules from a template of DNA ...

RNA gene scissors (CRISPR-Cas13) are gaining significant attention as a next-generation gene therapy with fewer side effects.

RNA modifications play crucial roles in gene regulation, cellular function and the response to environmental stimuli. However, the detection and characterization of these modifications remain ...

Deep within our nerve cells, a molecule is at work that has no beginning and no end. Instead of a straight chain, as is ...