Accurate extraction of molecular representations is a critical step in the drug discovery process. In recent years, significant progress has been made in molecular representation learning methods, ...

This approach allows for an unbiased dissection of multiple layers of cell state through a unified molecular strategy compatible with the widely used polyA capture chemistry in spatial transcriptomics ...

We describe a three-compartment rotaxane information ratchet in which the macrocycle can be directionally transported in either direction along an achiral (disregarding isotopic labeling) track.

The researchers designed DNA-based molecular cages that readily bound to all the RNA in the cells. These molecular cages can open when exposed to light, allowing for further chemical labeling.

Two new acentric borates, Li2Sr0.5[B3(BO3)4] (1) and Na4[Al3(BO3)4]·Cl (2), with cage-like frameworks constructed by BO3 and TO4 (T = B (1), Al (2)) units, were hydrothermally synthesized. The 3D ...

The 14-gene assay identified patients with molecular high risk who benefitted from adjuvant chemotherapy. Use of the assay to determine eligibility for adjuvant therapy in stage IA–IIA non-squamous ...