Obesity and rheumatic disease are mechanistically linked via chronic inflammation. The orphan receptor TREM-1 (triggering receptor expressed on myeloid cells-1) is a potent amplifier of ...

The DRiP hypothesis proposes that most peptides that bind to MHC class I molecules are derived from newly synthesized defective proteins. Here, the authors revise this hypothesis and propose that ...

Visualization of biological mechanisms by means of pathway graphs is necessary to better understand the often complex underlying system. Manual layout of such pathways or maps of knowledge is a ...

This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and ...

This study shows that oral—but not intravenous—lysozyme reshapes gut microbiota to reactivate PI3K–Akt signaling and reverse ...

The understanding of how macrophages regulate their response to toxic particles via two independent pathways could uncover therapeutic opportunities to quell inflammation BIRMINGHAM, Ala ...