The hyponatremia group developed early hyponatremia, defined as a serum sodium of 135 mmol/L or lower within 6 months after starting thiazide, vs. controls who had a serum sodium level between 136 ...

The investigators defined hyponatremia as a serum sodium value of 135 mEq/L or less, and classified hyponatremia as mild, moderate, or severe (131–135, 125–130, and less than 125 mEq/L ...

The primary outcome was hyponatremia, defined as blood sodium < 130 mmol/L, within 2 years of starting treatment. The 2-year incidence of hyponatremia for the two thiazide diuretics was 3.83% for ...

While targeted intervention improved hyponatremia in hospitalized patients, subsequent benefits in mortality and rehospitalization were not observed. News & Perspective Tools & Reference CME/CE.

References: Ayus JC, Moritz ML, Fuentes NA, et al. Correction rates and clinical outcomes in hospitalized adults with severe hyponatremia: a systematic review and meta-analysis. JAMA Intern Med ...