Redesign of the potent painkiller's core prevents breathing suppression and reduces addiction-related behaviours in mice ...

Secondary structure elements in protein molecules refer to local sub-conformational regions stabilized by hydrogen bonding. Assigning Secondary Structure Elements is crucial in protein structure ...

By hydrogen bonds forming and breaking between acid−base pairs and water molecules, protons transport directly through these poorly hydrophilic zones.

The nucleobase-metal bond primarily drives duplex formation, but hydrogen (H−) bonds may also be important for structure selection and stability. To elucidate the role of H-bonding, we conducted ...

Protein classification is a fundamental task in computational biology, aiding in function prediction and disease analysis. This study uniquely investigates the complementary role of secondary ...