The ion channel PIEZO2 doesn't just convey touch stimuli. It also plays a key role in the development of coronary vessels, a ...

A team of scientists at the MRC Laboratory of Medical Sciences (LMS) has uncovered a previously unknown mechanism that ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Looking to inspire the next generation of curious minds? These are our picks of the best popular science books for children ...

After binding with Programmed death-ligand 1(PD-L1), PD-1 inhibits proliferation and cytokins secretion of T cells by dephosphorylation of the T cell receptors (TCR) related molecules, and promotes ...

In this review, we focus on autocrine signaling in cardiomyocytes, endothelial cells, and fibroblasts, because they are the most abundant cell types in the heart. 7, 8 However, one has to keep in mind ...

How the T cell signaling network processes information to discriminate between self and agonist ligands. Proc. Natl. Acad. Sci. U.S.A. 117, 26020–26030 (2020). Crossref. PubMed. Google Scholar. 16. ..

Bispecific T cell engagers (TcEs) that are able to simultaneously bind to epitopes on cancer cells and T cells are a versatile, highly potent, and economical immunotherapeutic tool ().TcEs are ...