This conservation is evident through mutational constraints predicted by ESM2 and supported by direct analyses of multiple sequence alignments ... and frequently form continuous sequence motifs. The ...

our motif localization model achieved end-end motif localization function without multiple homologous sequences alignment. More importantly, our motif localization model has broad application ...

Figure 6 Phylogenetic tree made from the multiple sequence alignment (MSA) from the motifs of all the human haplotypes plus the chimpanzee (n=69). The leaf descriptions on the right include the ...

Abstract: Multiple sequence alignment (MSA) is a fundamental and key step for implementing other tasks in bioinformatics, such as phylogenetic analyses, identification of conserved motifs and domains, ...

As the third release within the Lasergene 11 series this summer, the primary focus for Lasergene 11.2 is to incorporate new sequence alignment methods and tools in the MegAlign Pro application.

For example, a set of sequences in an alignment might be interactively grouped on the basis of the user's own knowledge, or regions corresponding to aligned domains or sequence motifs might be ...

In this paper, we report on a simulation study that we performed to evaluate the consequences of using these new multiple sequence alignment methods in terms of the resultant phylogenetic ...