The histone lysine methyltransferase DOT1L (DOT1-like histone lysine methyltransferase) is responsible for the epigenetic regulation of gene expression through specific methylation of ... and clinical ...

Studies of immune cells and peripheral ... In this study, we will explore DNA methylation and histone acetylation, in the context of ECM gene expression, in ASM cells. We posit that epigenetic factors ...

Genotoxic stressors, including oxidative stress, inflammation, and environmental factors are closely intertwined processes that significantly contribute to ...

Epigenetic dysregulation has been strongly implicated in psychiatric disorders. Epigenetic modifications, such as DNA methylation and histone modifications ... The Lasting Consequences of Prenatal ...

The following is a summary of “Histone Modifications and DNA Methylation in Psoriasis: A Cellular Perspective,” published in the January 2025 issue of Allergy and Immunology by Pan et al. Epigenetic ...

Changes in these factors can play a critical role in disease. Epigenetics involves ... of these treatments aim to alter either DNA methylation or histone acetylation. Inhibitors of DNA methylation ...

This article was reviewed by Knox Beasley, MD. You might associate autoimmune conditions with symptoms like skin disease, chronic pain, and fatigue. A less-discussed symptom of autoimmune diseases?

In 2022, autoimmune diseases affected over 15 million individuals in the United States, with women nearly twice as likely to be affected as men and more than one third of affected individuals ...

Researchers have uncovered how chronic hepatitis C infection leads to autoimmune disease, which opens new paths for treatments Scientists at the Garvan Institute of Medical Research have ...

leading to higher rates of certain autoimmune disorders(1 Trusted Source The risk of immune-mediated inflammatory diseases following exposure to childhood maltreatment: A retrospective ...