The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the ...

Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. The chain of nucleosomes is then wrapped into a 30 nm spiral called a solenoid, ...

A recent study has revealed promising targets for treating childhood acute myeloid leukaemia (AML) driven by NUP98 fusion ...

DNA is wound around clusters of eight histone proteins (H1–H8), and together, histones and DNA make up chromatin.Histones not only keep DNA organized, but they are also known to help regulate ...

A recent review by Prof. Zhu Bing and Associate Professor Xiong Jun from the Institute of Biophysics of the Chinese Academy ...

For example, if a histone protein has 10 modification sites, bottom-up proteomics can tell you that those modifications exist but not whether all 10 are on the same histone at the same time.

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

During therapy, some cancer cells evolve to escape elimination. Newer anticancer drugs that can overcome this resistance are ...

Fruit ripening determines shelf life and consumer appeal, yet the molecular switches that control this process remain ...

Graphical abstract from “The fork protection complex promotes parental histone recycling and epigenetic memory” [Charlton et al. Cell 2024; DOI: 10.1016/j.cell.2024.07.017].

Histone mutational landscape of human cancers Date: March 1, 2021 Source: Princeton University Summary: Researchers have completed a comprehensive analysis of cancer-associated histone mutations ...

Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers. Proceedings of the National Academy of Sciences , 2024; 121 (52) DOI: 10.1073 ...