Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. The chain of nucleosomes is then wrapped into a 30 nm spiral called a solenoid, ...

DNA is wound around clusters of eight histone proteins (H1–H8), and together, histones and DNA make up chromatin.Histones not only keep DNA organized, but they are also known to help regulate ...

This study reveals that neutrophil extracellular traps (NETs) drive macrophage-derived chemokine production (CXCL9/10/11) to promote CD8+ T cell ...

For example, if a histone protein has 10 modification sites, bottom-up proteomics can tell you that those modifications exist but not whether all 10 are on the same histone at the same time.

A recent review by Prof. Zhu Bing and Associate Professor Xiong Jun from the Institute of Biophysics of the Chinese Academy ...

During therapy, some cancer cells evolve to escape elimination. Newer anticancer drugs that can overcome this resistance are ...

A recent study has revealed promising targets for treating childhood acute myeloid leukaemia (AML) driven by NUP98 fusion ...

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

So-called histone methyltransferases "also methylate a broad range of other protein substrates," Coonrod explains, noting that arginine methylation is a particularly widespread modification.

During therapy, some cancer cells evolve to escape elimination. Newer anticancer drugs that can overcome this resistance are necessary. Now, researchers from Japan demonstrate that aromatic ...

Histone mutational landscape of human cancers Date: March 1, 2021 Source: Princeton University Summary: Researchers have completed a comprehensive analysis of cancer-associated histone mutations ...

Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers. Proceedings of the National Academy of Sciences , 2024; 121 (52) DOI: 10.1073 ...