gut.bmj16d
Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer
Loss of SMAD4 induces PGK1 upregulation in PDAC, which enhances glycolysis and aggressive tumour behaviour. Notably, in SMAD4-negative PDAC, nuclear PGK1 preferentially drives cell metastasis via ...
Frontiers27d
The impact of glycolysis on ischemic stroke: from molecular mechanisms to clinical applications
During ischemic conditions, glycolysis replaces oxidative phosphorylation as the primary energy source for brain tissue. However, in the ischemia–reperfusion state, neuronal cells show a particular ...
C&EN1mon
Strong and Fireproof Regenerated Wood via a Combined Phosphorylation-Surface Nanofibrillation and Ionic Cross-Linking Strategy
Department of Chemistry, New Cornerstone Science Laboratory, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, ...
ahajournals.org1mon
Adrenomedullin 2/Intermedin Exerts Cardioprotective Effects by Regulating Cardiomyocyte Mitochondrial Function
and oxidative phosphorylation. The administration of exogenous AM2 alleviated heart failure following transverse aortic constriction. AM2 crucially regulates mitochondrial functions associated with ...
C&EN1mon
Synchronous Interference of Dual Metabolic Pathways Mediated by H 2 S Gas/GOx for Augmenting Tumor Microwave Thermal Therapy
Key Laboratory of Cryogenics Science and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Laboratory of Controllable Preparation and Application of Nanomaterials, ...
eLife1mon
Unveiling neoadjuvant chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing
Besides, pathways associated with energy metabolisms such as glycolysis and hypoxia were up-regulated in myofibroblast, whereas pericyte was characterized by enriched oxidative phosphorylation and ...
Frontiers1y
Human papillomavirus-associated head and neck squamous cell carcinoma cells rely on glycolysis and display reduced oxidative phosphorylation
This study aims to characterize the metabolism of HPV-positive and HPV-negative HNSCC cell lines. Methods: Oxidative phosphorylation (OXPHOS) and glycolysis were assessed in intact cells, in four ...