Time to update textbooks on electron transport chain in mitochondria, researchers say
In an article published in the journal Trends in Biochemical Sciences, Alicia Kowaltowski, full professor at the University ...
EurekAlert!2d
Researchers advocate ‘rewriting’ of textbooks on electron transport chain in mitochondria
A paper by scientists affiliated with the University of São Paulo highlights new discoveries regarding the mechanisms of oxidative phosphorylation involved in ATP production. Recent studies have ...
gut.bmj18d
Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer
Loss of SMAD4 induces PGK1 upregulation in PDAC, which enhances glycolysis and aggressive tumour behaviour. Notably, in SMAD4-negative PDAC, nuclear PGK1 preferentially drives cell metastasis via ...
Frontiers29d
The impact of glycolysis on ischemic stroke: from molecular mechanisms to clinical applications
During ischemic conditions, glycolysis replaces oxidative phosphorylation as the primary energy source for brain tissue. However, in the ischemia–reperfusion state, neuronal cells show a particular ...