The addiction of cancer cells to causal gene fusions often results in amplification, in vivo, which can be exploited to reveal unidentified recurrent gene rearrangements. Based on this observation, we ...

A new case report was published in Volume 16 of Oncotarget on February 5, 2025, titled “Acquired RUFY1-RET rearrangement as a ...

It is also the first to validate an oncogenic ligand as a target," she noted. "Gene fusions are usually the receptor that is abnormal, but this is a novel genetic target in that it is the ligand ...

UTRECHT, The Netherlands and CAMBRIDGE, Mass., Feb. 05, 2025 (GLOBE NEWSWIRE) -- Merus N.V. (Nasdaq: MRUS) (Merus, the Company, we, or our), a ...

The Phase II eNRGy trial showed durable antitumor activity with zenocutuzumab (Bizengri) in patients with NRG1 ...

A new case report was published in Volume 16 of Oncotarget on February 5, 2025, titled "Acquired RUFY1-RET rearrangement as a mechanism of resistance to lorlatinib in a patient with CD74-ROS1 ...

In the second study, Nallasivan Palanisamy and co-workers report that 1–2% of prostate cancers harbor gene fusions involving RAF kinase genes, rather than classical ETS family transcription factors.

We have investigated the prediction of protein interactions through the analysis of domain fusion to assess whether metabolic enzymes have a higher participation in gene-fusion events compared ...

Prognostic factors for thermo-ablation of liver metastases in colon cancer: A Maltese perspective. Impact of sirtuin genes expression on first-line treatment outcomes in patients (pts) with metastatic ...

Association between skeletal muscle morphometrics and overall survival among older adults with gastrointestinal cancers. Gene rearrangements/fusions identified per year.

A new case report details a novel genetic mutation linked to drug resistance in a non-small cell lung cancer patient ...