CRISPR construct to genetically ablate the GABA transporter GAT3 in the mouse visual cortex, with effects on population-level neuronal activity. This work is important, as it sheds light on how GAT3 ...

Researchers have developed a groundbreaking computational model that provides detailed insights into the vesicle cycle, a key process in synaptic transmission. Their model predicts parameters ...

This paper focuses in concrete at processes done at synaptic cleft zone where neural synapse carries out information through the pass of neurotransmitters from neuron to other. Mainly, ...

Selective enhancement of synaptic GABA signaling mediated by GABA-A receptors has been previously reported to promote functional recovery after ischemic stroke, while tonic GABA signaling has been ...

When the neurotransmitter binds to the neuron on the other side of the synaptic cleft, that post-synaptic neuron may change in some way.

A Georgetown University pharmacology and physiology professor gave an overview of “The World of GABA” in the annual Stephen and Mary Krop Lectureship in Pharmacology April 12. Dr. Paul Krop (CAS ’65, ...

Ca2+ dependent release of Cr upon stimulation Classical neurotransmitters are released from the SVs into the synaptic cleft in a Ca 2+ dependent manner after stimulation. For example, high ...

While the understanding of GABA's action at the synapse between pre- and post-synaptic neurons has been established, its effects outside the synapse have remained a mystery.