In both cases, the receptor was studied in complex with endogenous mammalian GnRH and the Gq protein. The researchers determined cryo-EM structures for the frog and pig GnRHR–Gq complexes at ...

The researchers used cryo-electron microscopy (cryo-EM) to determine the structure of the human EP1 receptor in complex with PGE2 and the heterotrimeric Gq protein, completing the structural ...

The Gq-coupled receptor-signaling pathway has been implicated in the cardiac hypertrophic response to stress, but little is actually known about the contributions of Gq signaling in either the heart ...