Neuromodulators that activate Gq-coupled receptors exert powerful control over brain function. Here, the authors develop a fluorescence lifetime sensor capable of imaging protein kinase C activity ...

Neuromodulators that activate Gq-coupled receptors exert powerful control over brain function. Here, the authors develop a fluorescence lifetime sensor capable of imaging protein kinase C activity ...

This important study fills an gap in our knowledge of the evolution of GPCRs in holozoans, as well as the phylogeny of associated signaling pathway components such as G proteins, GRKs, and RIC8 ...

Thus, G-protein-coupled receptors can regulate NMDA receptor function indirectly through a PKC-dependent activation of the non-receptor tyrosine kinase (Src) signaling cascade.

During animal development, cells divide and arrange themselves in a coordinated way, eventually forming the embryo. The cells ...

G protein-coupled receptors articles from across Nature Portfolio G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand ...

However, efforts to determine the receptor’s structure have been hampered for decades by its low expression levels and inherent instability, leaving unresolved questions about how GnRH activates ...

Now, in a collaborative study, Merchier and De Strooper's research groups have identified the orphan G protein-coupled receptor GPR3 as a potential new therapeutic target for Alzheimer's disease ...

"G-protein-coupled receptors are ubiquitous in the function of cells in the body and help us to sense light, flavour and odour. They are also responsible for the human body's reactions to chemicals in ...

Everywhere you look, men are drinking matcha. How the green tea coffee alternative ended up at the center of a gendered debate.

Since 1978, Brunello Cucinelli has sought to lead his luxury empire—and the town that became its heart—with benevolence. And with the industry bracing for tariffs and trade wars, protecting ...