On the intracellular side, the EP1 receptor engaged Gq protein through both conserved and receptor-specific interactions. Residues such as R63 ICL1, E294 6.32, and Q298 6.36 contributed to the ...

The researchers used cryo-electron microscopy (cryo-EM) to determine the structure of the human EP1 receptor in complex with PGE2 and the heterotrimeric Gq protein, completing the structural ...

Although G protein-coupled receptors (GPCRs) are crucial to the regulation of most functions in the human body, very little is known about how they work. In a new study, researchers at the Biozentrum ...

Neuromodulators that activate Gq-coupled receptors exert powerful control over brain function. Here, the authors develop a fluorescence lifetime sensor capable of imaging protein kinase C activity ...

Neuromodulators that activate Gq-coupled receptors exert powerful control over brain function. Here, the authors develop a fluorescence lifetime sensor capable of imaging protein kinase C activity ...