When GTP on Gα is hydrolyzed, the inactive Gαβγ heterotrimer re-associates for a new cycle of activation by the GPCR (Fig. 1). The GTP hydrolysis is strongly stimulated by a group of GAP (GTPase ...

UCSF researchers have identified ADGRG1, a microglial receptor that helps clear amyloid beta plaques in Alzheimer’s disease.

Without the receptor, ADGRG1, the microglia barely nibbled on the toxic protein. Using a mouse model of Alzheimer’s disease, the researchers observed how the loss of ADGRG1 led to the rapid buildup of ...

Osteoblasts are specialised bone cells responsible for building and regenerating bone tissue. Researchers at Leipzig University have shown in a high-profile study that a specific receptor plays a key ...

Without the receptor, ADGRG1, the microglia barely nibbled on the toxic protein. Using a mouse model of Alzheimer's disease, ...

Twenty years ago, Roger Cone, Ph.D. made a key discovery in obesity science which could help Courage Therapeutics deliver ...

UCSF scientists have discovered how microglia engulf and break down amyloid beta, a protein that builds up in Alzheimer's, ...

Microglia, a type of brain immune cell, can gobble up amyloid beta protein, which clumps together into toxic aggregates ...

Scientists at UCSF have uncovered how certain immune cells in the brain, called microglia, can effectively digest toxic ...

In Alzheimer's disease, proteins like amyloid beta form clumps, known as plaques, that damage the brain.But in some people, ...