GPCRs have two principal signal transduction pathways that can be detected via the second messengers, cyclic AMP (cAMP), and phosphatidylinositol (IP), a metabolic product of IP3 (Figure 1).

At right: A ribbon diagram of the G protein ... Food and Drug Administration. “GPCRs are important drug targets mainly due to their involvement in signaling pathways related to many diseases ...

The team was able to define the way in which proteins called beta arrestins (for their role in stopping signals) also turn on pathways that ... coupled receptors (GPCRs) on the cell surface ...

GPCR signaling pathways are crucial to our survival. They are the largest pharmaceutical drug target -- more than one-third of all drugs on the market -- because GPCR pathways regulate the body by ...

The second pathway is mediated by a completely different G protein-coupled set of cellular receptors (GPCRs). Both classes of receptors deliver molecular messages from outside to inside the cell and ...

The discovery of this novel cell signaling pathway revises the previous 'on ... a G-protein coupled receptor (GPCR) embedded in the membranes of nerve cells. "This is a whole new way of ...

a member of the family of G protein-coupled receptors (GPCRs), which can be combined with and significantly improve the tumor-killing effects of adenosine pathway inhibitors. GPR174-targeting ...

PIP2 is an important phosphoinositide that is present in around 1% of the plasma membrane. It is also involved in signal transduction of intracellular and extracellular components. There are two ...