In vivo base editing enables precise, single-nucleotide changes to DNA without double-strand breaks. A recent application in ...

Our genomic DNA is comprised of four bases—cytosine (C), thymine (T), guanine (G) and adenosine (A). These bases join together into approximately 3 billion different base pairs, arranged in a ...

However, under certain conditions, a single strand of DNA can fold into a G-quadruplex (G4) structure, which looks like a knot. These knots often form in regions with many guanine (G) bases.

image: Red arrows indicate the nuclear spin axes at the positions of the N3 nitrogen atoms on the guanine (G) bases. Due to the helical structure of DNA, there is an angular deviation in the ...

To date, people have encoded information into DNA the same way nature has, by linking the four nucleotide bases comprising DNA—A, T, C, and G—into a particular genetic sequence.

Our genomic DNA is comprised of four bases—cytosine (C), thymine (T), guanine (G) and adenosine (A). These bases join together into approximately 3 billion different base pairs, arranged in a ...