Ubiquitination is an important post-translational modification that regulates protein stability, activity, and cellular localization through a cascade reaction involving E1 activating enzymes, E2 ...

TVB-3567 is a potent and selective small molecule FASN inhibitor, planned to enter clinical development for the treatment of acne. The IND with the U.S. Food and Drug Administration’s Division ...

Sagimet Biosciences Inc. has obtained IND clearance from the FDA for TVB-3567 (ASC-60), a selective small-molecule fatty acid synthase (FASN) inhibitor set to enter clinical development for the ...

Sagimet Biosciences (SGMT) announced the clearance of its Investigational New Drug, IND, application for TVB-3567, the Company’s second fatty acid synthase, FASN, inhibitor. TVB-3567 is a potent ...

Sagimet Biosciences cleared an IND for TVB-3567, a FASN inhibitor for acne, with Phase 1 trials planned for 2025. Sagimet Biosciences Inc. announced the clearance of its Investigational New Drug ...

TVB-3567 is the Company’s second fatty acid synthase (FASN) inhibitor First-in-human Phase 1 trial initiation planned in 2025 SAN MATEO, Calif., March 11, 2025 (GLOBE NEWSWIRE) -- Sagimet ...

Enzymes are molecular machines that carry out the chemical reactions that sustain all life, an ability that has captured the attention of scientists like me. Consider muscle movement. Your body ...

TVB-3567 is a potent and selective small molecule FASN inhibitor, planned to enter clinical development for the treatment of acne. The IND with the U.S. Food and Drug Administration’s Division of ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. We aimed to restore MHC-I expression on the ...