At the same time, mTECs are inefficient at presenting exogenous antigens. mTEC-derived antigens can also be transferred to and presented by conventional dendritic cells (cDCs) in the thymus.

The MHC class I system mediates presentation of endogenous or intracellularly-produced proteins. The MHC class II system mediates presentation of exogenous or externally-produced antigens.

Antigen Presentation and Evolution of Immune Response The evolving immune response, from initial antigen exposure to cancer cell cytotoxicity and memory T-cell formation, can be manipulated to evade ...