Using cryo-EM, researchers elucidated the structure of key receptors integral to fast excitatory synaptic transmission in the rat cerebellum.

However, the receptor's low expression levels and instability have long hindered efforts to resolve its structure, leaving questions about how GnRH activates GnRHR unanswered.

Chronic pain affects millions of people in the US. Targeting an oft-overlooked brain receptor could one day offer relief.

We’ve known for nearly a century that UV radiation is linked to skin cancer, but modern advice about sunburn can be confusing. To understand what works, you need to know what UV really does to ...

Why you should think twice before having a hot shower or bath - While really hot showers and baths often feel lovely and can help you relax, there are some potential downsides ...

Boston, MA – June 12, 2025 — Receptor.AI, a leading AI-driven drug discovery company, today announced the incorporation of the REAXENSE TM platform, developed by Reaxense Inc., a Canadian chemical and ...

The epidermis expresses a series of transient receptor potential receptors (TRPs), which localize to the upper layer of the epidermis where they monitor and direct responses to fluctuations in ...

Vepdegestrant is an oral proteolysis-targeting chimera (PROTAC) estrogen receptor (ER) degrader that directly harnesses the ubiquitin–proteasome system. In this phase 3, open-label, randomized ...

G protein-coupled receptors are embedded in the cell membrane and transmit signals from the outside to the inside of the cell. Because of their vast diversity and crucial role in the body, GPCRs ...

FcRn protects IgG and albumin from catabolism, transports IgG across the placenta, and regulates IgG function. Blocking or augmenting FcRn can decrease autoimmune antibodies and enhance drug delivery.

Research reveals dopamine receptor ratios, not just dopamine levels, impact Ritalin's effectiveness for ADHD, potentially personalizing treatment.