Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and antioxidant defenses, plays a central role in the development of non-communicable diseases (NCDs).

A deep mechanistic understanding of enzyme-substrate interactions is a first step toward the design and successful use of small-molecule therapeutics for AD. The key finding of Arafi et al. is that ...

In this context, it should be noted that no FAD-mutant enzyme is completely deficient in proteolytic activity; substrate interaction with the mutant protease is apparently critical to pathogenesis.

Enzyme concentration Increasing enzyme concentration can increase the rate of reaction, as there are more enzyme molecules available to catalyse the reaction, leading to more frequent enzyme-substrate ...

Traditionally, enzyme–substrate interaction is simulated with the help of the Michaelis–Menten model, which is a nonlinear dynamic system. On the other hand, previous studies have paid little ...

The third difficulty is the enzyme-substrate interaction, including spatial hindrances. Problems like steric obstruction (Rothschild, 1998), jamming of enzymes (Willams, 2005), and unproductive ...

Spread the loveIntroduction: In the world of biochemistry and enzyme kinetics, understanding how enzymes function and interact with their substrates is critical. Two essential parameters for ...

This reveals an additional, targetable interaction site for potential inhibitors. There are several polar residues (E768, N782, and E798) located at one edge of the sandwich pocket that show ...

Chen and colleagues examined the interactions and charge densities of enzyme and substrate atoms for two enzymatic reactions: the isomerisation of 5-androstene-3,17-dione (5-AND) catalysed by ...