The authors proposed two hypotheses: first, that methamphetamine induces neuroinflammation, and second, that it alters neuronal stem cell differentiation. These are valuable hypotheses, and the ...

Connexin 41.8 governs timely haematopoietic stem and progenitor cell specification. Haematopoietic stem and progenitor cells ...

Since the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), understanding the mechanisms underlying ...

The ion channel PIEZO2 doesn't just convey touch stimuli. It also plays a key role in the development of coronary vessels, a team led by Annette Hammes from the Max Delbrück Center reports in Nature ...

The formation of blood vessels is a complex process involving the interplay of proteins and mechanical forces. In two studies ...

Cell–cell junctions, such as adherens junctions, compromise VE-cadherin, PECAM-1, vascular endothelial growth factor 2 (VEGFR2), and VEGFR3. At the basal site of the endothelium is the contact to the ...

When blood moves through your body, it exerts a frictional force on the walls of blood vessels. This force, known as fluid shear stress, has important effects on vascular development, function, and ...

This ADAM10-mediated proteolysis could be induced by Ca 2+ influx and staurosporine treatment, indicating that ADAM10-mediated VE-cadherin cleavage contributes to the dissolution of adherens junctions ...

By transcriptome analysis, we found that the cell-cell junction, cadherin binding, cytoskeleton and classical signaling pathways such as MAPK and Rho GTPase of endothelial cells were regulated by ...

It affects several vital organs, seemingly through a pathological effect on endothelial cells. The SARS-CoV-2 genome encodes 29 proteins, whose contribution to the disease manifestations, and ...

Graphical Abstract Endothelial-to-mesenchymal transition is a dynamic process in which endothelial cells suppress constituent endothelial properties and take on mesenchymal cell behaviors. To begin ...