The schematic illustration of their proposed clonal selection and diversification in normal endometrial epithelium is shown in Figure 1, where each color represents an expanding clone.

In a recent study published in Nature Communications, Simón and his research team analyzed patient cells and patient-derived endometrial organoids to decode an Asherman syndrome-specific endometrial ...

As a proof-of-concept, they then used this model to show how the hormone-dependent behaviors of the endometrial epithelium in co-culture with stroma are different from those in monoculture.

After obtaining the endometrial samples, they purified single-cell suspensions of epithelial and stromal cells that were cultured in very low amounts. They found that a small number of these cells ...

Initial cultures of epithelial and stromal endometrial cells from human donors in the hydrogel remained intact for 15 days, outperforming those grown in Matrigel, which had begun disintegrating by the ...

Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk. Med, 2023; 4 (8): 554 DOI: 10.1016/j.medj.2023.07.004 ...

Endometrial cancer—in which tumors develop in the inner lining of the uterus—is the most prevalent gynecological cancer in ...

Then they cultured endometrial stromal and epithelial organoids from human donors together in the synthetic matrix, and the co-culture remained intact over the experiment period of at least 15 days.

Scientists in the U.K. have succeeded in deriving endometrial organoids using cells extracted from menstrual blood, opening the way to more relevant high-throughput screens for drug discovery and to ...