In a recent study published in Nature Communications, Simón and his research team analyzed patient cells and patient-derived endometrial organoids to decode an Asherman syndrome-specific endometrial ...

As a proof-of-concept, they then used this model to show how the hormone-dependent behaviors of the endometrial epithelium in co-culture with stroma are different from those in monoculture.

Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk. Med, 2023; 4 (8): 554 DOI: 10.1016/j.medj.2023.07.004 ...

Endometrial cancer—in which tumors develop in the inner lining of the uterus—is the most prevalent gynecological cancer in ...

The schematic illustration of their proposed clonal selection and diversification in normal endometrial epithelium is shown in Figure 1, where each color represents an expanding clone.

After obtaining the endometrial samples, they purified single-cell suspensions of epithelial and stromal cells that were cultured in very low amounts. They found that a small number of these cells ...

Initial cultures of epithelial and stromal endometrial cells from human donors in the hydrogel remained intact for 15 days, outperforming those grown in Matrigel, which had begun disintegrating by the ...

By studying endometrial tissue samples from five healthy women and 12 women with PCOS, the researchers created a cell map of individual cells. The women were all of similar age, weight and BMI and ...

The mutational landscape of normal human endometrial epithelium. Nature, 2020; DOI: 10.1038/s41586-020-2214-z ...

“Epithelial cells were seeded in the upper chamber, stromal cells in the lower,” Camara de Bem said. “Both cell types are abundant in the endometrium.