In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations ...

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using ...

New research identified a protein called protein disulfide isomerase that helps repair serious DNA damage, providing a target ...

A new study published in Aging Cell reveals that a well-known enzyme, long known for its involvement with cancer, actually steps into the nucleus to help repair DNA. This enzyme is Protein Disulphide ...

Reference: Clarke TL, Cho HM, Ceppi I, et al. ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome. Nat Cell Biol. 2025;27 (6):1006-1020. doi: ...

Researchers discovered a previously unknown function of RNA, potentially opening the door to new ways to treat cancer and ...

Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a double-strand break ...

We found that RNA can actively guide the repair process of double-strand breaks. It does this by binding to broken DNA ends, helping align sequences of DNA on a matching strand that isn't broken.

Homologous recombination (HR) is one of the key DNA repair pathways in cells. It is essential for repairing double-stranded breaks in DNA and for DNA crossover events during sexual reproduction.

More information: Wei Wu et al, VGLL3 modulates chemosensitivity through promoting DNA double-strand break repair, Science Advances (2024). DOI: 10.1126/sciadv.adr2643 ...

Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a dangling ...

A new research paper was published in Aging's Volume 15, Issue 19, entitled, “Reduction of double-strand DNA break repair exacerbates vascular aging.” ...