In this Review, familial and sporadic neurological disorders reported to have an etiological link with DNA repair defects are discussed, with special emphasis placed on the molecular link between ...

Single-strand breaks generated during DNA repair were observed converting to double-strand breaks and reversibly switching between states in response to oxidation in cultured neurons as well as in ...

Homologous recombination is a DNA repair mechanism that allows cells to correct double-strand breaks, one of the most severe types of damage. This process uses a similar DNA sequence as a template to ...

Advances in CRISPR technologies promise to accelerate the burgeoning pipeline of gene-editing therapies and broaden access to these disease-altering therapies.

In a Phase I/II trial, patients with X-linked chronic granulomatous disease will receive a treatment created using a new ...

People genetically susceptible to Huntington's disease often see their movement, mood, and cognition decline slowly over time.

That information exists in a code — deoxyribonucleic acid (DNA) — the blueprint for life. That code is stored in dense, coiled structures called chromosomes. A single strand of DNA within a ...

How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...