Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a double-strand break invol ...

We found that RNA can actively guide the repair process of double-strand breaks. It does this by binding to broken DNA ends, helping align sequences of DNA on a matching strand that isn't broken.

DNA double-stranded breaks threaten genome stability. Here, the authors show that transcript RNA serves as a repair template in human cells and identify Polζ as a key factor in RNA-templated DSB ...

Reference: Clarke TL, Cho HM, Ceppi I, et al. ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome. Nat Cell Biol. 2025;27 (6):1006-1020. doi: ...

More information: Thomas L. Clarke et al, ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome, Nature Cell Biology (2025). DOI: 10.1038/s41556-025-01674-1 ...

New research identified a protein called protein disulfide isomerase that helps repair serious DNA damage, providing a target ...

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations ...

Moving toward clinical development, the researchers demonstrated efficient delivery of mRNA mitochondrial base editors using ...

CRISPR–Cas9 technology works by creating double-strand breaks (DSBs) in DNA to enable gene editing.

By shifting the DNA repair preference toward homologous recombination (HR), the team achieved 1.7- to 9.8-fold improvements in GT efficiency at specific tomato loci.

CRISPR–Cas9 technology works by creating double-strand breaks (DSBs) in DNA to enable gene editing. However, most of these breaks are repaired through an error-prone process called nonhomologous ...