Franklin W. Stahl, an American molecular biologist whose landmark 1957-58 experiment with colleague Matthew Meselson revealed ...

In the new study, Spies’ team used cryogenic electron microscopy (CryoEM) to show that RAD52 proteins form an unexpected spool-like structure composed of two rings of RAD52, each containing 11 copies ...

This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights ...

Significantly, iMs also induce breakage of nascent DNA. Finally, stalled forks are only rescued by a specialised helicase, Pif1, but not Rrm3, Sgs1, Chl1 or Hrq1. Altogether, we provide a mechanism ...

Replicative helicases are hexameric rings in all domains of life (1 – 3). In bacteria and archaea, the replicative helicase is a homohexamer and encircles single-strand (ss) DNA at a replication fork.

The nephew of a man killed in New York City 15 years ago has been arrested for his murder after officials obtained DNA evidence on a plastic fork connecting him to the slaying.

Browse 1,000+ dna replication stock illustrations and vector graphics available royalty-free, or search for rna or protein synthesis to find more great stock images and vector art. rna protein ...

DNA replication. biological process of producing two identical replicas from one original molecule. replication fork. Vector diagram shows how both strands of the DNA helix are unzipped and copied.

Finally, we resolve the DNA-bound structure of the N-terminal BRCT domain in the context of RFC:PCNA:DNA complexes and demonstrate that this domain promotes PCNA loading at replication forks in vitro.

(B) When the ongoing DNA replication fork is blocked by DNA lesions, such as ICLs, upstream factors recognize it, and PCNA is monoubiquitinated by RAD6/RAD18. We hypothesize that monoubiquitinated ...