This study provides valuable findings on the role of site-specific DNA methylation changes during spermatogenesis and their contribution to paternal epigenetic inheritance. The study proposes that ...

The article is published in the journal Frontiers of Medicine. These modifications, which include DNA methylation, histone modifications, chromatin remodeling, and RNA modifications, are crucial ...

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

Mutations fuel evolution while also causing diseases like cancer. Epigenome-targeted DNA repair can help organisms protect important genomic regions from mutation. However, the adaptive value, ...

DNA methylation is a key factor in the regulation of organismal development and tissue homeostasis. DNA methylation marks indicate how to regulate ...

Because links between DNA methylation and heterochromatin proteins were suggested in the literature, we thought that DNA methylation might be depleted in Purkinje ... Lab safety rules dictate that one ...

Drug exposure not only affects gene transcription levels but also influences transcriptional adaptations in specific cell types by altering epigenetic marks, including DNA methylation and histone ...

The scientists state that epigenetic clocks based on the entropy of methylation states predict chronological age with ...

Histone modification is an epigenetic mechanism that enables fine-tuning of gene expression. Mutation or dysregulation of proteins associated with histone modification (called “writers,” “erasers,” ...

“ […] methylation entropy is measuring different properties of a locus compared to mean methylation and CHALM, and that loci ...