(2001) demonstrated that the budding yeast protein Mrc1 is the replication checkpoint transducer ... However, prolonged RF stalling leads to DNA damage; alternatively, the fork may collapse ...

Another important checkpoint takes place later in the cell cycle, just before a cell moves from G 2 to mitosis. Here, a number of proteins scrutinize the cell's DNA, making sure it is structurally ...

these DNA damage checkpoints may now be relevant to treating viral infections of the small DNA viruses under investigation at UB. "Because they rely almost exclusively on host cell enzymes to ...

Our data suggest that in human cells, the complex acts as a sensor of DNA damage that participates in the activation of cell cycle checkpoints following g-irradiation. This interpretation stems from ...

The S phase checkpoint is a kinase signaling cascade that is activated in response to DNA damage or fork stalling during replication ... fork blocks before entry into mitosis by inducing cell cycle ...

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DNA repair systems recognize it as DNA damage and trigger a form of permanent cell cycle arrest called replicative senescence, which may lead to cell death called apoptosis. 5 This checkpoint is ...

They investigated whether allografts are sensitive to immune checkpoint blockade ... To determine whether the cell cycle synthesis (S)-phase-specific DNA damage caused by CDK12 loss is associated ...