A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...
Mitochondrial defects, however, are associated with the development of diseases such as type 2 diabetes. Patients who suffer from this disorder are unable to produce enough insulin or use the insulin ...
Extended cash runway into late 2027, beyond a potentially registration-enabling azenosertib data readout from DENALI Part 2 Planned workforce reduction of approximately 40% of employees Corporate ...
These findings provide new research tools and insights for studying ROS damage in highly folded and stacked DNA structural domains within the cell nucleus. (30,31) Further quantitative analysis of the ...
Viability screening of 146 targeted drugs identified ATR kinase inhibitor Elimusertib to broadly synergize with Gemcitabine across 13 PDAC cell lines. Phosphoproteomics revealed strong DNA damage ...
DNA damage can persist unrepaired for years, particularly in blood stem cells, increasing the risk of mutations and cancer. This discovery challenges traditional views on mutation processes and ...
FARGO, N.D.--(BUSINESS WIRE)--Aldevron, a global leader in the production of DNA, RNA and protein, has launched its latest innovation, Alchemy™ cell-free DNA technology. This revolutionary technology ...
The redness, inflammation, and pain of sunburn may stem from damage to RNA, not DNA. “Sunburn damages the DNA, leading to cell death and inflammation. So the textbooks say,” said Assistant ...
Srs2 binding to PCNA and its sumoylation contribute to RPA antagonism during the DNA damage response
Activation of the DNA damage checkpoint upon genotoxin treatment induces a multitude of cellular changes, such as cell cycle arrest or delay, to cope with genome stress. After prolonged genotoxin ...
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