The second messenger cyclic di-AMP (c-di-AMP) plays a pivotal role in bacterial physiology by regulating osmolyte transport, potassium uptake, cell wall integrity and the overall stress response.

We found that the levels of c-di-AMP and (p)ppGpp, two nucleotide second messengers that are highly conserved throughout the microbial world, coexist in a homeostatic loop in the facultative ...

Cyclic di-AMP (cdiA) is a second messenger predicted to be widespread in Gram-positive bacteria, some Gram-negative bacteria, and Archaea. In the human pathogen Listeria monocytogenes, cdiA is an ...

Cyclic AMP (cyclic adenosine 3′,5′-monophosphate) is a second messenger and one of the most important intracellular mediators. Changes in intracellular cAMP levels correlate with GPCR activation.

Archive Role of Cyclic AMP in Hormone Actions Author: R. W. Butcher, Ph.D. Author Info & Affiliations Published December 19, 1968 N Engl J Med 1968;279: 1378 - 1384 ...