Granzyme K activates the entire complement cascade. Nature, 2025; DOI: 10.1038/s41586-025-08713-9 ...

Well, there are drugs out there that only target a certain aspect of the complement cascade, like C5 or C3. With Annexon targeting Cq1, it takes out all cascades at the source.

For some people, IgA deposits in IgAN trigger the body’s complement cascade, creating more deposits of C3, similar to those seen in C3G. C3 deposits aren’t present in all cases of IgAN.

Genetic data from NEI’s Age Related Eye Disease Studies have suggested roles for C8 proteins, as well as other proteins higher up in the complement cascade, in AMD.

To test this out, the researchers assessed levels of C1q and also C3b—an activated complement protein further down the cascade—in symptomatic and presymptomatic patients with genetic ...

In the periphery, pentraxins bind C1q. Pentraxin-3, a long pentraxin distinct from short ones made in the liver, contains a C-reactive protein domain and it can bind C1q to activate the complement ...

Silence Therapeutics plc, Nasdaq: SLN (“Silence” or “the Company”), an experienced and innovative biotechnology company committed to transforming peop ...

In this article, ACROBiosystems discusses how the complement cascade and it's various components could potentially be leveraged for therapeutic potential in COVID-19, cancer and general inflammation.

Researchers investigated the complement component 1q (C1q) binding and subsequent complement activation by neutralizing antibodies (nAbs) produced following COVID-19 vaccination.