Under the new leadership of Marty Makary, the FDA should focus more attention on the critical role of real-world clinical data — such as from health insurance databases — in the ongoing assessment of ...

In an interview with Fortune, Isomorphic Labs president Colin Murdoch shared that four years after its founding, the company ...

Scientists have refined a new way of using genetics to identify whether someone has type 1 or type 2 diabetes in Chinese ...

Results of subgroup analysis (SA) reported in randomized clinical trials (RCT) cannot be adequately interpreted without information about the methods used in the study design and the data analysis.

Objective To document clinical trial data flow in global clinical trials published in major journals between 2013 and 2021 from Global South to Global North.Design Scoping analysisMethods We performed ...

Introduction This study protocol describes a trial designed to investigate whether high-flow heated and humidified nasal oxygen (HFHO) therapy in patients with hypercapnic acute respiratory failure ...

Background Well designed and properly executed randomised trials are considered the most reliable evidence on the benefits of healthcare interventions. However, there is overwhelming evidence that the ...

How to design medtech clinical trials that deliver March 25, 2025 By Scott Nelson [Image from Pixabay] Transparent, well-designed clinical trials are a must. Here’s advice on how to get there.

Introduction There is conflicting evidence regarding the benefits of percutaneous coronary intervention (PCI) in patients with grey zone fractional flow reserve (GZFFR artery) values (0.75–0.80). The ...

Nonrandomized studies have suggested that the use of balloon guide catheters may improve rates of vessel recanalization, first-pass effect (complete vessel recanalization after the first thrombectomy ...

Clinical trial risk-based monitoring, or RBM, can be applied at various stages of trials to identify and mitigate risks affecting the clinical trial. One type of RBM uses some components of site ...

Improving Protocol Design with RWD Protocol design is the backbone of any clinical trial, outlining study objectives, patient selection criteria, endpoints, and procedures.