Scientists at Stanford University have created a faster way to design enzymes. They use machine learning, computer models, and “cell-free systems” to predict how enzymes will behave. This lets ...

Enzymes play a key role in cellular metabolic processes. To enable the quantitative assessment of these processes, researchers need to know the so-called 'turnover number' (for short: kcat) of the ...

With so many enzymes in the new model, it now makes sense why drugs that increase NO levels are not interchangeable. "The assumption is that they all work the same way to increase NO.

These enzymes are important for cleaning up the cellular environment, and they also set the threshold for what is considered an infection or not. I'm hoping someday we may be able to help patients ...

Membrane-associated proteins play a vital role in a variety of cellular processes, yet little is known about the membrane-association mechanism. Lipoprotein-associated phospholipase A2 (Lp-PLA2 ...

In this model, an enzyme’s active site is a specific shape, and only the substrate will fit into it, ... Since they are not destroyed during the process, a cell can reuse each enzyme repeatedly.

The researchers, after ruling out other signaling enzymes, were able to show that the signaling enzyme MARK2 has this role. "Further studies of this previously unrecognized signaling pathway should ...

The paper's lead author is Hexin Shi, Ph.D., a postdoctoral researcher in the Center, who identified the gene for the enzyme and then worked to characterize the enzyme's role as a new component of ...

Both enzymes degrade nucleic acids via a two-step process. “We call this process a two-step catalysis: bite down and release,” says Yuan. “In the first step, the enzyme bites down on the DNA strand ...

Plants have neither supportive bone tissue nor muscles, and yet they can form rigid structures like stalks and even tree trunks. This is due to the fact that plant cells are enveloped by a stable cell ...

They use machine learning, computer models, and “cell-free systems” to predict how enzymes will behave. This lets them test thousands of designs on a computer before building the best ones in ...