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Cataplexy is a type of sudden weakness in your muscles that can make you go limp or temporarily lose your ability to move. Here’s what you need to know about the symptoms, causes, and treatments.

Cataplexy is a condition that can range from barely noticeable muscle weakness to a complete blackout. Learn more about this sudden loss of voluntary muscle tone when strong emotions are ...

Orexins are chemicals in your brain that help your body stay awake. When you have narcolepsy, you don’t have enough neurons that make orexins.

Imagine repeatedly falling asleep or falling down paralyzed when laughing or startled. This is life with narcolepsy, which can be triggered by an infection or the flu.

Narcolepsy type 1 is a disorder of hypersomnolence caused by a loss of orexin neurons, which results in low orexin levels in the brain. In this phase 2, randomized, placebo-controlled trial, partic ...

A recent paper describes six cases where cataplexy was initially diagnosed, but in all cases the weakness spells were eventually not attributed to cataplexy.

Narcolepsy type 1 is caused by severe loss or lack of brain orexin neuropeptides. We conducted a phase 2, randomized, placebo-controlled trial of TAK-994, an oral orexin receptor 2–selective ...

A large percentage of people with narcolepsy have cataplexy as well, which along with excessive sleepiness disrupts a person’s ability to socialize, work at a job, drive a car or even have close ...

Narcolepsy may stem from the lack of the neurotransmitter hypocretin. It is a long-term neurological condition that causes fragmented sleep, daytime sleepiness, brain fog, and other symptoms.