The discovery of the Bcl-2 protein family, as well as p53 and its involvement in regulating apoptosis, and the CD95 (also known as FAS or APO1) pathway, led to an understanding of the molecular ...

The two apoptosis pathways of interest are the extrinsic ... (DRs), and the intrinsic pathway is tightly controlled by the BCL-2 family of proteins and involves the disruption of mitochondrial ...

Caenorhabditis elegans drp-1 and fis-2 Regulate Distinct Cell-Death Execution Pathways Downstream of ced-3 and Independent ... release of caspase activators from mitochondria during apoptosis. Here we ...

ABT199/venetoclax, an inhibitor of the pro-survival BCL-2 protein, has improved AML treatment ... suggests potent activation of apoptosis by this two-drug combination; increased levels of γ ...