John Seymour, MBBS, FRACP, PhD, explains why BCL-2 was considered an undruggable target for so long and what led to the development of effective BCL-2 inhibitors.

The two apoptosis pathways of interest are the extrinsic ... (DRs), and the intrinsic pathway is tightly controlled by the BCL-2 family of proteins and involves the disruption of mitochondrial ...

15 This mutation causes SOD1 to bind and block an anti-apoptotic protein, B cell lymphoma-2 (BCL-2), in spinal cord neurons, which promotes aberrant apoptosis. In Parkinson’s disease, mutant Parkin ...

Figure 2: Inhibition of caspase 3, apoptosis (caspase ... distinct cellular stress pathways and signal that a stress has occurred through interactions with other BCL-2 family members.

Alopecia is an autoimmune disorder that causes non-scarring hair loss on the scalp and body that is experienced by almost 2% ...

and change in the mRNA levels of BCL-2/Bax, PTEN, and CDK4 as a consequence of MYC downregulation. Moreover, the researchers analyzed the effects of miR-377 on apoptosis, proliferation ...