Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters ...

When we compared the timing of anaphase onset in cells with reduced USP44, Mad1 or Mad2 function by time-lapse imaging, we found that USP44 depletion markedly accelerated the onset of anaphase, ...