In relapsing-remitting multiple sclerosis, activation of the peripheral immune system can lead to focal inflammation within the CNS. Over the past three decades, therapeutic development has been ...

Emerging research suggests that a daily coffee habit may contribute to longevity and improved aging. Beyond alertness, ...

Highly prized agarwood, used in medicine, is rare. New research shows that growing high-quality agarwood sustainably requires ...

Neuronal AMP-activated protein kinase modulates this process, the authors found. Knocking it out exacerbated lipid droplets in the glia, while activating the kinase alleviated them. However, it’s ...

Smoothened/AMP-Activated Protein Kinase Signaling in Oligodendroglial Cell Maturation Alice Del Giovane 1 Mariagiovanna Russo 2 Linda Tirou 2 Hélène Faure 2 Martial Ruat 2 Sonia Balestri 1 Carola ...

Background: AMP-activated protein kinase (AMPK) is a therapeutic target against type II diabetes (T2D). Synthetic sesquiterpene derivatives were investigated to identify novel AMPK activators as ...

Sirtuin 1 Activation Contributes to Sal A-Induced AMP-Activated Protein Kinase Activation and Uncoupling Protein 1 Upregulation Both AMPK and SIRT1 activation improved thermogenic program in ...

AMP-activated protein kinase (AMPK) is an important energy sensor located in cells throughout the human body. From the periphery, AMPK is known to be a metabolic master switch controlling the use of ...

The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeostasis, which acts to restore energy homoeostasis whenever cellular energy charge is depleted. Over ...

Bmf upregulation was prevented by Compound C, an inhibitor of adenosine monophosphate-activated protein kinase, indicating Bmf expression may be induced in response to bioenergetic stress.

Abstract AMP-activated protein kinase (AMPK) is a stress-activated kinase that functions as a cellular fuel gauge and master metabolic regulator. Recent investigation has elucidated novel molecular ...