This can be a limitation in cross-linking studies where efficient recoveries of the cross-linked peptides are critical. To overcome this limitation, we have developed a modification to the standard in ...

Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

Proteins have specific biological functions in cells through conformational changes and interactions. Therefore, precise, in situ analysis of protein complex changes is essential for understanding ...

We showed that Schiff bases form between the diamines of minoxidil and aldehyde-modified hyaluronic acid, leading to cross-linking and formation of injectable hydrogels. Hydrogels exhibited tunable ...