We found that the amplitude of the glycine-activated Cl− current was enhanced after application of purified Gβγ or after activation of a G protein–coupled receptor.

Constitutively activated G α q/11 proteins drive the vast majority of uveal melanoma (UM). GQ262 effectively combats UM both in vitro and in vivo by targeting G α q/11 directly.

Rhodopsin then activates G proteins, which, in turn, activate other enzymes. It is the number of G protein molecules activated by one rhodopsin molecule that the new experiments challenge, Yau says.

The ability of protein kinases to transfer a phosphate group to target proteins plays an important role in many cellular ...

Unlike many other light-activated G protein-coupled receptors, it can be activated without a light stimulus and is thus permanently active; researchers call this constitutively active.

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

Researchers in biology and medicine have long dreamed of controlling the activities of cells without, for example, having to use chemicals. After all, in a structure as complex as an entire organism, ...

The activated G protein then modulates the activity of other proteins and signaling pathways. GPCRs are targets of many drugs designed to influence those pathways, including treatments for ulcers ...

Harvard Medical School scientists have identified a key protein in the human immune system that drives inflammatory and autoimmune conditions when it turns against the body.

Activated charcoal is a supplement used to treat acute poisoning, but its benefits for other uses, like whitening teeth, preventing hangovers, and aiding kidney function, need more research. Here ...

G-protein coupled receptors (GPCRs) play pivotal roles in signaling pathways and are the most common membrane proteins. Implicated in many diseases, they are an attractive therapeutic target ...