A new study led by Children's Hospital Los Angeles has found a novel mechanism behind neuroblastoma progression: the shape and structure of the extracellular matrix.

While their functions are diverse, myosins are similar in structure. NMII is so much like cardiac myosin, which keeps the ...

A decade ago, the existence of Asgard archaea was unknown. However, in 2015, researchers analyzing deep-sea sediments uncovered gene fragments that suggested the presence of a new, previously ...

Researchers at Kanazawa University report in eLife on deciphering the actin structure-dependent preferential cooperative binding of cofilin. The actin filament is a double-stranded helical ...

HS-AFM and Principal Component Analysis provide experimental evidence to substantiate the 'proof of principle' regarding the flexible helical twists of actin filaments that regulate the functions of ...

Formins are highly dynamic proteins that assemble filaments rapidly, hence it is difficult to obtain enough filament ends for detailed structure determination. The MPI scientists analyzed not just one ...

Ions regulate the assembly and mechanical properties of actin filaments. Recent work using structural bioinformatics and site-specific mutagenesis favors the existence of two discrete and specific ...

The solution of the cryoEM structure of the cardiac thin filament in calcium-free and calcium-bound states by Yamada et al. revealed many key relationships between tropomyosin, actin, and troponin.

We find that filament severing, enhanced near barbed ends, can explain the single molecule actin lifetime distribution, if oligomer fragments reanneal to free ends with rate constants comparable to in ...

Actin filaments do not function in a naked state, and actin binding proteins (ABP) s regulate all aspects of actin, that is, actin filament dynamics and organization are regulated by various ABPs. In ...

A Japanese research group using microscopic video analysis provides deeper insight into the mechanics of plant cell division. Their analysis shows that actin filaments control the shape of cell ...