Proteins are life's molecular workhorses, doing everything from turning sunlight into food to fighting viruses. They are ...

This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state ...

Because the variant was located close to an established GATA binding site, we next explored the potential GATA factor-dependent regulation of luciferase activity in transient transfection experiments.

FcRn protects IgG and albumin from catabolism, transports IgG across the placenta, and regulates IgG function. Blocking or augmenting FcRn can decrease autoimmune antibodies and enhance drug delivery.

These results collectively highlight that the core binding affinity of GAS2-CH3 to F-actin is predominantly mediated by the ABD1, ABD2’, and ABD2 sites, underscoring the functional importance of these ...

Atomistic molecular dynamics simulations showed that binding the CA motif of the nucleation-promoting factor Neuronal Wiskott-Aldrich Syndrome Protein (N-WASp) to inactive, splayed Arp2/3 complex ...

High-resolution structures of Myosin-IC reveal a unique actin-binding orientation, ADP release pathway, and power stroke trajectory ...

Rationale: Myosin binding protein C’s (MyBP-C) interaction with the actin thin filament has been supported by numerous biochemical and modeling studies but the data are contradictory with respect to ...

These inhibitors aim to halt metastasis by preventing fascin from binding actin filaments and gathering them into bundles within filopodia. Immobilized, the cancer cells are stopped in their tracks.

Fascin is a major actin-binding protein (ABP) for stabilizing filopodia to support efficient adhesion and migration of cancer cells. Fascin is also highly expressed in metastatic tumors. Disrupting ...

The analysis of protein-ligand binding sites plays a crucial role in the initial stages of drug discovery. Accurately predicting the ligand types that are likely to bind to protein-ligand binding ...

They found a relatively small fraction of Myo10 (6%) localizes to filopodia. There are hundreds of Myo10 in each filopodia, which suggests some filopodia have more Myo10 than actin binding sites. Thus ...