Cell culture plays an important role in a wide range of biological research, from modelling diseases, to testing drug toxicity, to manufacturing vaccines. Traditionally, cultures have been planar, ...

We designed a rhesus macaque 2D choroid plexus epithelial cell culture, as well as a modified 3D cell culture model, in order to study activation, diffusion, and migration through the choroid plexus.

In 2D cell culture, the monolayer and the microenvironment do not imitate the in vivo conditions. The data accumulated using 2D models do not offer a clear understanding of the research ...

The classically preferred model is a static dish culture system which mainly generates adherent two-dimensional (2D) cell monolayers. Still, such culture systems do not reflect the situation in ...

3D cell culture is the future of drug discovery and disease research. Scientists have relied on 2D cell culture and animal models for many years, but these models often fail to accurately replicate ...

A growing body of evidence suggests that more relevant, translational observations can be made using 3D microtissues and organoids as compared to 2D monolayer cell culture. This is most notable in ...

2D cell culture is generally insufficient at reflecting the in vivo behavior of an organ, and it can be difficult to translate research conducted in 2D cultures to the bedside. As a result, animal ...

There are several different 3D cell culture types, including scaffold-free spheroids and scaffold-based organoids. 3 The combination of 3D cell culture with microfluidics has yielded the ...

Olivier Pardo and colleagues at the Cellular Regulatory Networks Group, Imperial College, London, use a combination of 2D and 3D cell culture assays and whole zebrafish models to study the ...